NMDAR1 (phospho Ser896) Antibody
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產(chǎn)品名稱: NMDAR1 (phospho Ser896) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
NMDAR1 (phospho Ser896) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。NMDAR1 (phospho Ser896) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
NMDAR1 (phospho Ser896) Antibody
的詳細介紹
NMDAR1 (phospho Ser896) AntibodyProduct Profile
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Product Name
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NMDAR1 (phospho Ser896) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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NMDA receptors are members of the ionotropic class of glutamate receptors, which also includes Kainate and AMPA receptors. NMDA receptors consist of NR1 subunits combined with one or more NR2 (A-D) or NR3 (A-B) subunits. The ligand-gated channel is permeable to cations including Ca2+, and at resting membrane potentials NMDA receptors are inactive due to a voltage-dependent blockade of the channel pore by Mg2+. NMDA receptor activation, which requires binding of glutamate and glycine, leads to an influx of Ca2+ into the postsynaptic region where it activates several signaling cascades, including pathways leading to the induction of long-term potentiation (LTP) and depression (LTD). NMDA receptors have a critical role in excitatory synaptic transmission and plasticity in the CNS. They govern a range of physiological conditions including neurological disorders caused by excitotoxic neuronal injury, psychiatric disorders and neuropathic pain syndromes.1) Tyszkiewicz JP, et al. J Physiol. 2004 Feb 1; 554 (Pt 3): 765-777
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Immunogen
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NMDAR1 (Phospho-Ser896) antibody was raised against a peptide sequence around phosphorylation site of serine 896 (R-R-S (p) -S-K) derived from Human NMDAR1.
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NMDAR1 (phospho Ser896) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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NMDAR1 (phospho Ser896) AntibodyTarget Information
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Gene Symbol
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GRIN1
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Alternative Names
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NR1
MRD8
GluN1
NMDA1
NMDAR1
BBC6
BCL2L8
GLURZ1
GRIN1
NMD-R1
NMDZ1
NMZ1
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Molecular Weight(MW)
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120 kDa
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Tissue Specificity
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This antibody detects endogenous level of NMDAR1 only when phosphorylated at serine896.
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NMDAR1 (phospho Ser896) AntibodyDatabase Links
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Entrez Gene
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2902
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Protein Accession
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NP_000823.4
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NMDAR1 (phospho Ser896) AntibodyApplication
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Application
Western blot analysis of lysed extracts from Mouse Brain tissue using NMDAR1 (Phospho-Ser896).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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