ABL1 (phospho Thr735) Antibody
如果您對該產品感興趣的話,可以
產品名稱: ABL1 (phospho Thr735) Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
ABL1 (phospho Thr735) Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。ABL1 (phospho Thr735) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
ABL1 (phospho Thr735) Antibody
的詳細介紹
ABL1 (phospho Thr735) AntibodyProduct Profile
|
Product Name
|
ABL1 (phospho Thr735) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1.1) Fainstein E., Oncogene 4:1477-1481(1989).
More
|
|
Immunogen
|
ABL1 (phospho Thr735) antibody was raised against a peptide sequence around phosphorylation site of threonine735 (S-V-T (p)-L-P) derived from Human ABL1.
|
ABL1 (phospho Thr735) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
WB
|
|
|
Western Blot: 1:500~1:1000:
|
|
Species Reactivity
|
HumanMouseRat
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
ABL1 (phospho Thr735) AntibodyTarget Information
|
Gene Symbol
|
ABL1
|
|
Alternative Names
|
Abelson murine leukemia viral oncogene 1
ABL1
c-ABL
JTK7
p150
More
|
|
Molecular Weight(MW)
|
135 kDa
|
|
Tissue Specificity
|
The antibody detects endogenous levels of ABL1 only when phosphorylated at threonine 735.
|
ABL1 (phospho Thr735) AntibodyDatabase Links
|
Entrez Gene
|
25
|
|
Protein Accession
|
NP_005148.2
|
ABL1 (phospho Thr735) AntibodyApplication
-
Application
Western blot analysis of extracts from COS cells treated with EGF using ABL1 (Phospho-Thr735) Antibody. The lane on the right is treated with the antigen-specific peptide.
|
Application Notes
|
Western Blot: 1:500~1:1000:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
