Inhibits the activity of dimeric NF-κ-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to tranlocate to the nucleus and activate transcription.1) Beraud C, et al. (1999) Proc Natl Acad Sci U S A 96 (2): 429-434. Sundstrom S, et al. (2005) J Virol 79 (4): 2230-2239. Liu L, et al. (1998) Mol Cell Biol 18 (7): 4221-4234. Shrivastava A, et al. (1998) J Virol 72 (12): 9722-9728. Franzoso G, et al. (1997) Genes Dev 11 (24): 3482-3496. More
IkB-a (Ab-42) antibody was raised against a peptide sequence around aa. 40~44 (E-E-Y-E-Q) derived from Human IkappaB-α.
IHCWB
HumanMouseRat
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using IkappaB-α (Ab-42).
Western blot analysis of lysed extracts from 293 and THP1 cells using IκB-α (Ab-42).
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