Amyloid Precursor Protein Antibody
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產品名稱: Amyloid Precursor Protein Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
Amyloid Precursor Protein Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。Amyloid Precursor Protein Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
Amyloid Precursor Protein Antibody
的詳細介紹
Amyloid Precursor Protein AntibodyProduct Profile
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Product Name
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Amyloid Precursor Protein Antibody
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Antibody Type
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Primary Antibodies
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Product description
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A large body of evidence has implicated the amyloid precursor protein (APP) in the pathogenesis of Alzheimer's disease (AD) (Kamenetz et al., 2003). The phosphorylation of APP at Thr668 is thought to play a critical role in generation of the soluble APP (beta) and beta-amyloid peptide (abeta) which are the major components of senile plaques in patient brains inflicted with AD (Liu et al., 2003; Ando et al., 2001).1) Ando K, Iijima KI, Elliott JI, Kirino Y, Suzuki T (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of beta-amyloid. J Biol Chem 276:40353-40361.
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Immunogen
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Peptide corresponding to amino acid residues from the C-terminal region of rat APP.
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Amyloid Precursor Protein AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Species Reactivity
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DogHumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Amyloid Precursor Protein AntibodyTarget Information
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Gene Symbol
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App
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Alternative Names
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Abeta
ABPP
APP
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Molecular Weight(MW)
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115
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Amyloid Precursor Protein AntibodyDatabase Links
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Entrez Gene
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54226
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Protein Accession
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P08592
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Amyloid Precursor Protein AntibodyApplication
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Application
Western blot of rat hippocampal lysate showing specific immunolabeling of the ~115k APP protein.
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Application Notes
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The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with canine, chicken, human, mouse and non-human primate tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Amyloid Precursor Protein antibody can be stored at -20?C and is stable at -20?C for at least 1 year.
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Storage Buffer
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100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.
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