op18 Antibody: Op18 belongs to the stathmin family of genes and encodes a ubiquitous cytosolic phosphoprotein that may function as an intracellular relay integrating several signaling pathways such as those involved in cell proliferation and differentiation. Op18 has also been shown to be involved in the regulation of the microtubule filament system by destabilizing microtubules, thereby preventing assembly and promoting the disassembly of microtubules. More recently, op18 has been implicated as a potential target of the ASK1-p38 MAP kinase cascade, suggesting that the ASK1-p38 cascade may regulate microtubule dynamics through op18. Op18 is highly expressed in a wide variety of human malignancies, including leukemia, prostate cancer, ovarian carcinoma, and breast carcinoma, suggesting that op18 may be an ideal target for anti-cancer therapeutics.1) Curmi PA, Gavet O, Charbaut E, et al. Stathmin and its phosphoprotein family: general properties, biochemical and functional interaction with tubulin. Cell Structure and Function1999; 24:345-57. More
Op18 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human op18. The immunogen is located within the first 50 amino acids of op18.
ELISAIFIHC-PWB
HumanMouseRat
Immunohistochemistry of op18 in human brain tissue with op18 antibody at 2.5 μg/mL.
Western blot analysis of op18 in human brain tissue lysate with op18 antibody at (A) 0.5 and (B) 1 μg/mL.
Immunofluorescence of op18 in human brain tissue with op18 antibody at 20 μg/mL.
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