如果您對該產品感興趣的話,可以
產品名稱: a Synuclein Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
a Synuclein Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。a Synuclein Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
a Synuclein Antibody
的詳細介紹
a Synuclein AntibodyProduct Profile
|
Product Name
|
a Synuclein Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
SncA is a member of the synuclein family of structurally related proteins that are prominently expressed in the central nervous system, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and SncA and Snc-Beta inhibit phospholipase D2 selectively. SncA may serve to integrate presynaptic signaling and membrane trafficking. Aggregated SncA proteins form brain lesions that are hallmarks of neurodegenerative synucleinopathies. Defects in SncA play a role in the pathogenesis of Parkinson disease. SncA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer disease. SncA shares 95% sequence homology with rat SncA. Rat SncA is specifically expressed in brain and is associated with synaptosomal membranes in neurons1) Takahashi T, et al. J Biol Chem 2003 Oct 24; 278 (43): 42225-33Ahn BH, et al. J Biol Chem 2002 Apr 05; 277 (14): 12334-42Negro A, et al. FASEB J 2002 Feb; 16 (2): 210-2Goldberg, et al. Nat. Cell Biol. 2000; 2, 115-119.
|
|
Immunogen
|
a-Synuclein (Ab-129) antibody was raised against a peptide sequence around aa.127~131 (M-P-S-E-E) derived from Human α-Synuclein.
|
a Synuclein AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
WB
|
|
|
Western Blot: 1:500~1:1000:
|
|
Species Reactivity
|
HumanMouseRat
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
a Synuclein AntibodyTarget Information
|
Gene Symbol
|
SNCA
|
|
Alternative Names
|
PD1
NACP
PARK1
PARK4
SYN
SYUA
alpha-synuclein
|
|
Molecular Weight(MW)
|
18 kDa
|
|
Tissue Specificity
|
This antibody detects endogenous level of total Synuclein protein.
|
a Synuclein AntibodyDatabase Links
|
Entrez Gene
|
6622
|
|
Protein Accession
|
NP_000336.1
|
a Synuclein AntibodyApplication
-
Application
Western blot analysis of lysed extracts from Mouse Brain tissue using α-Synuclein (Ab-129).
|
Application Notes
|
Western Blot: 1:500~1:1000:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
