CDC25A is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. CDC25A is an oncogene, although its exact role in oncogenesis has not been demonstrated.1) Ito, Y., et al., Int. J. Mol. Med. 13(3):431-435 (2004). More
This Cdc25A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 271-300 amino acids from the Central region of human Cdc25A.
IHC-PWB
Human
Western Blot at 1:2000 dilution + HCT116 whole cell lysate Lysates/proteins at 20 ug per lane.
Formalin-fixed and paraffin-embedded human Spleen tissue reacted with Cdc25A Antibody , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
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