HER2 (phospho Tyr1248) Antibody
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產(chǎn)品名稱(chēng): HER2 (phospho Tyr1248) Antibody
產(chǎn)品型號(hào):
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無(wú)相關(guān)文檔
簡(jiǎn)單介紹
HER2 (phospho Tyr1248) Antibody迅速增長(zhǎng)的產(chǎn)品線(xiàn)包括一抗、二抗、**測(cè)定及細(xì)胞檢測(cè)試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。HER2 (phospho Tyr1248) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
HER2 (phospho Tyr1248) Antibody
的詳細(xì)介紹
HER2 (phospho Tyr1248) AntibodyProduct Profile
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Product Name
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HER2 (phospho Tyr1248) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.1) Yuan, Lu Qian, Ming Shi, et al. (2008) HER2-dependent MMP-7 expression is mediated by activated STAT3 Guogang Cellular Signalling, 20:1284–1291.
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Immunogen
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HER2 (Phospho-Tyr1248) antibody was raised against a peptide sequence around phosphorylation site of tyrosine1248 (P-E-Y (p) -L-G) derived from Human HER2.
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HER2 (phospho Tyr1248) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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HER2 (phospho Tyr1248) AntibodyTarget Information
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Gene Symbol
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ERBB2
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Alternative Names
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NEU
NGL
HER2
TKR1
CD340
HER-2
MLN19
HER-2/neu
AMPK1
C-erbB-2
ErbB2
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Molecular Weight(MW)
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185 kDa
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Tissue Specificity
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This antibody detects endogenous level of HER2 only when phosphorylated at tyrosine1248.
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HER2 (phospho Tyr1248) AntibodyDatabase Links
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Entrez Gene
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2064
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Protein Accession
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NP_001005862.1
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HER2 (phospho Tyr1248) AntibodyApplication
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using HER2 (Phospho-Tyr1248). Bottom Image: Immunofluorescence staining of methanol-fixed MCF7 cells using HER2 (Phospho-Tyr1248).
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Application
Western blot analysis of lysed extracts from MDA cells untreated or treated with EGF using HER2 (Phospho-Tyr1248).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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