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產(chǎn)品名稱: CTNNB1 Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
CTNNB1 Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。CTNNB1 Antibody嚴(yán)格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
CTNNB1 Antibody
的詳細(xì)介紹
CTNNB1 AntibodyProduct Profile
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Product Name
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CTNNB1 Antibody
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Antibody Type
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Primary Antibodies
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Product description
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The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.1) Huang, W., et al. Mol. Cell. Biol. 30(19):4575-4594(2010)
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Immunogen
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This CTNNB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 723-751 amino acids from the C-terminal region of human CTNNB1.
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CTNNB1 AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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Ig
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Host Species
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Rabbit
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Tested Applications
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WB
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For WB starting dilution is: 1:1000:
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Species Reactivity
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Human
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Concentration
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1mg/ml
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Purification
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Affinity purified
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CTNNB1 AntibodyTarget Information
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Gene Symbol
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CTNNB1
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Alternative Names
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Catenin beta-1
Beta-catenin
CTNNB1
CTNNB
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Molecular Weight(MW)
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85 kDa
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Sequence Similarities
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Predicted species reactivity based on immunogen sequence: Bovine
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CTNNB1 AntibodyDatabase Links
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Entrez Gene
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1499
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Protein Accession
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P35222
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CTNNB1 AntibodyApplication
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Application
Western blot analysis in T47D cell line lysates (35ug/lane).
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Application
Western Blot at 1:1000 dilution Lane 1: 293 whole cell lysate Lane 2: Hela whole cell lysate Lysates/proteins at 20 ug per lane.
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Application Notes
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For WB starting dilution is: 1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store at 4?C for three months and -20?C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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Storage Buffer
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Supplied in PBS with 0.09% (W/V) sodium azide.
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