p70 S6 Kinase (phospho Ser424) Antibody
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產(chǎn)品名稱: p70 S6 Kinase (phospho Ser424) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
p70 S6 Kinase (phospho Ser424) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p70 S6 Kinase (phospho Ser424) Antibody嚴格的質(zhì)量控制和驗證實驗包括各種不同的應(yīng)用：WB、細胞**熒光、**組化、流式細胞術(shù)、ELISA、CHIP、IP和peptide array。
p70 S6 Kinase (phospho Ser424) Antibody
的詳細介紹
p70 S6 Kinase (phospho Ser424) AntibodyProduct Profile
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Product Name
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p70 S6 Kinase (phospho Ser424) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation.1) Satoru Eguchi et al. (1999) J Biol Chem, Vol. 274: 36843-36851Papst PJ, et al. (1998) J Biol Chem. 273 (24): 15077-84. Ulrike Krause et al. (2002) Eur. J. Biochem. 269: 3751-3759 cLe, X. F, et al. (2003) Oncogene 22: 484–97
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Immunogen
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p70 S6 Kinase (Phospho-Ser424) antibody was raised against a peptide sequence around phosphorylation site of serine 424 (P-V-S (p) -P-V) derived from Human p70 S6 Kinase.
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p70 S6 Kinase (phospho Ser424) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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IFIHCWB
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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p70 S6 Kinase (phospho Ser424) AntibodyTarget Information
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Gene Symbol
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RPS6KB1
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Alternative Names
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S6K
PS6K
S6K1
STK14A
p70-S6K
p70S6KA
p70-alpha
S6K-beta-1
p70(S6K)-alpha
HCP
PTP1C
KS6B1
P70-S6K
RPS6KB1
S6K
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Molecular Weight(MW)
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70, 85 kDa
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Tissue Specificity
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This antibody detects endogenous level of p70 S6 Kinase only when phosphorylated at serine 424.
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p70 S6 Kinase (phospho Ser424) AntibodyDatabase Links
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Entrez Gene
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6198
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Protein Accession
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NP_003152.1
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p70 S6 Kinase (phospho Ser424) AntibodyApplication
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Application
Top Image: Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p70 S6 Kinase (Phospho-Ser424). Bottom Image: Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic, centrosomal and nuclear staining using p70 S6 Kinase (Phospho-Ser424).
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Application
Western blot analysis of lysed extracts from MCF cells untreated or treated with EGF using p70 S6 Kinase (Phospho-Ser424).
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Application Notes
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Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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