FAK (phospho Tyr576) Antibody
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產品名稱: FAK (phospho Tyr576) Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
FAK (phospho Tyr576) Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。FAK (phospho Tyr576) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
FAK (phospho Tyr576) Antibody
的詳細介紹
FAK (phospho Tyr576) AntibodyProduct Profile
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Product Name
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FAK (phospho Tyr576) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.1) Tong L, et al. (2013)Biochim Biophys Acta 1833, 1304-15. Chen S, et al. (2013)Sci Signal 6, ra40. Tian H, et al. (2012)EMBO J 31, 3885-900.
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Immunogen
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FAK (phospho Tyr576) antibody was raised against a peptide sequence around phosphorylation site of Tyrosine576 (S-T-Y (p)-Y-K) derived from Human FAK.
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FAK (phospho Tyr576) AntibodyKey Feature
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Clonality
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Polyclonal
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Isotype
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IgG
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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HumanMouseRat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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FAK (phospho Tyr576) AntibodyTarget Information
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Gene Symbol
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PTK2
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Alternative Names
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FADK 1
FAK1
Focal adhesion kinase 1
PTK2
pp125FAK
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Molecular Weight(MW)
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125 kDa
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Tissue Specificity
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The antibody detects endogenous level of FAK only when phosphorylated at tyrosine 576.
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FAK (phospho Tyr576) AntibodyDatabase Links
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Entrez Gene
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5747
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Protein Accession
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NP_001186578.1
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FAK (phospho Tyr576) AntibodyApplication
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Application
Western blot analysis of extracts from NIH-3T3 tissue using FAK (Phospho-Tyr576) Antibody. The lane on the right is treated with the antigen-specific peptide.
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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