Tau (phospho Ser416) Antibody
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產(chǎn)品名稱: Tau (phospho Ser416) Antibody
產(chǎn)品型號:
產(chǎn)品展商: immunoclone
產(chǎn)品文檔: 無相關(guān)文檔
簡單介紹
Tau (phospho Ser416) Antibody迅速增長的產(chǎn)品線包括一抗、二抗、**測定及細(xì)胞檢測試劑盒、蛋白/多肽、激動(dòng)劑/拮抗劑/活化劑/抑制劑及裂解物等。Tau (phospho Ser416) Antibody嚴(yán)格的質(zhì)量控制和驗(yàn)證實(shí)驗(yàn)包括各種不同的應(yīng)用：WB、細(xì)胞**熒光、**組化、流式細(xì)胞術(shù)、ELISA、CHIP、IP和peptide array。
Tau (phospho Ser416) Antibody
的詳細(xì)介紹
Tau (phospho Ser416) AntibodyProduct Profile
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Product Name
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Tau (phospho Ser416) Antibody
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Antibody Type
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Primary Antibodies
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Product description
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Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5 (1-2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1, 3).1) Johnson, G. V. and Stoothoff, W. H. (2004) J. Cell Sci. 117, 5721-5729. Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476. Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
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Immunogen
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Tau (phospho-Ser416) antibody was raised against a peptide sequence around phosphorylation site of serine 416 (T-G-S (p) -I-D) derived from Rat Tau.
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Tau (phospho Ser416) AntibodyKey Feature
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Clonality
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Polyclonal
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Host Species
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Rabbit
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Tested Applications
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WB
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Western Blot: 1:500~1:1000:
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Species Reactivity
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Rat
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Concentration
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1mg/ml
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Purification
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Affinity purified
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Tau (phospho Ser416) AntibodyTarget Information
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Gene Symbol
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Mapt
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Alternative Names
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pTau
Mtapt
RNPTAU
Mapt
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Molecular Weight(MW)
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48, 62, 78 kDa
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Tissue Specificity
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This antibody detects endogenous levels of Tau only when phosphorylated at serine 416.
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Tau (phospho Ser416) AntibodyDatabase Links
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Entrez Gene
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29477
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Protein Accession
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NP_058908.2
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Tau (phospho Ser416) AntibodyApplication
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Application
Western blot analysis of extract from rat brain, rat hippocampus and mouse brain using Tau (phospho-Ser416).
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Application Notes
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Western Blot: 1:500~1:1000:
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Additional Information
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Form
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Liquid
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Storage Instructions
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Store antibody at -20?C for up to one year.
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Storage Buffer
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Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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