MAPT is differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. The mutations in the gene have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.1) Reynolds, M.R., (2006) Biochemistry 45 (13), 4314-4326. More
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human MAPT.
ELISAWB
Human
Antibody used in WB on N2A at 1:2000 (Lane 1: 10ug N2A expressed human Tau-C Lane 2: 10ug N2A expressed human Tau-E Lane 3: 10ug N2A expressed human Tau-F Lane 4: 10ug N2A expressed human Tau-B Lane 5: 10ug N2A expressed human Fetal-Tau Lane 6: 10ug N2A expressed human Tau-D Lane 7: 10ug N2A expressed human much Fetal-Tau Lane 8: 10ug N2A lysate ).
Antibody used in WB on Human HepG2 at 0.2-1 ug/ml.
Antibody used in IHC on mouse cortex at: 1:1000.
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