p53 (phospho Ser6) Antibody
如果您對該產品感興趣的話,可以
產品名稱: p53 (phospho Ser6) Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
p53 (phospho Ser6) Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p53 (phospho Ser6) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
p53 (phospho Ser6) Antibody
的詳細介紹
p53 (phospho Ser6) AntibodyProduct Profile
|
Product Name
|
p53 (phospho Ser6) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Lin T, et al. (2005) Nat Cell Biol; 7 (2): 165-71. Vega FM, et al. (2004) Mol Cell Biol; 24 (23): 10366-80. Li J, et al. (2004) J Biol Chem; 279 (40): 41275-9. Wang J, et al. (2004) J Biol Chem; 279 (38): 39584-92.
More
|
|
Immunogen
|
p53 (Phospho-Ser6) antibody was raised against a peptide sequence around phosphorylation site of serine 6 (P-Q-S (p) -D-P) derived from Human p53.
|
p53 (phospho Ser6) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
IHCWB
|
|
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
|
|
Species Reactivity
|
HumanMouse
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
p53 (phospho Ser6) AntibodyTarget Information
|
Gene Symbol
|
TP53
|
|
Alternative Names
|
P53
BCC7
LFS1
TRP53
CHK1
Antigen NY-CO-13
Phosphoprotein p53
TP53
Tumor suppressor p53
More
|
|
Molecular Weight(MW)
|
53 kDa
|
|
Tissue Specificity
|
This antibody detects endogenous level of p53 only when phosphorylated at serine 6.
|
p53 (phospho Ser6) AntibodyDatabase Links
|
Entrez Gene
|
7157
|
|
Protein Accession
|
NP_000537.3
|
p53 (phospho Ser6) AntibodyApplication
-
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Ser6).
-
Application
Western blot analysis of lysed extracts from HT29 and HeLa cells untreated or treated with UV using p53 (Phospho-Ser6).
|
Application Notes
|
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100:
|
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
