p53 (phospho Thr387) Antibody
如果您對該產品感興趣的話,可以
產品名稱: p53 (phospho Thr387) Antibody
產品型號:
產品展商: immunoclone
產品文檔: 無相關文檔
簡單介紹
p53 (phospho Thr387) Antibody迅速增長的產品線包括一抗、二抗、**測定及細胞檢測試劑盒、蛋白/多肽、激動劑/拮抗劑/活化劑/抑制劑及裂解物等。p53 (phospho Thr387) Antibody嚴格的質量控制和驗證實驗包括各種不同的應用：WB、細胞**熒光、**組化、流式細胞術、ELISA、CHIP、IP和peptide array。
p53 (phospho Thr387) Antibody
的詳細介紹
p53 (phospho Thr387) AntibodyProduct Profile
|
Product Name
|
p53 (phospho Thr387) Antibody
|
|
Antibody Type
|
Primary Antibodies
|
|
Product description
|
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.1) Zakut-Houri R., EMBO J. 4:1251-1255(1985).
More
|
|
Immunogen
|
p53 (phospho Thr387) antibody was raised against a peptide sequence around phosphorylation site of threonine 387 (F-K-T (p)-E-G) derived from Human p53.
|
p53 (phospho Thr387) AntibodyKey Feature
|
Clonality
|
Polyclonal
|
|
Isotype
|
IgG
|
|
Host Species
|
Rabbit
|
|
Tested Applications
|
IHC
|
|
Species Reactivity
|
Human
|
|
Concentration
|
1mg/ml
|
|
Purification
|
Affinity purified
|
p53 (phospho Thr387) AntibodyTarget Information
|
Gene Symbol
|
TP53
|
|
Alternative Names
|
TP53
tumor protein p53
Tumor suppressor p53
|
|
Molecular Weight(MW)
|
43 kDa
|
|
Tissue Specificity
|
The antibody detects endogenous levels of p53 only when phosphorylated at threonine 387.
|
p53 (phospho Thr387) AntibodyDatabase Links
|
Entrez Gene
|
7157
|
|
Protein Accession
|
NP_000537.3
|
p53 (phospho Thr387) AntibodyApplication
-
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using p53 (Phospho-Thr387) antibody (left) or the same antibody preincubated with blocking peptide (right).
Additional Information
|
Form
|
Liquid
|
|
Storage Instructions
|
Store antibody at -20?C for up to one year.
|
|
Storage Buffer
|
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
|
