Product Name	c-Myc Antibody (C-19)
Antibody Type	Tags Antibodies
Modification Notes	c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Myc proteins are nuclear proteins with relatively short half lives. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. The L-Myc gene has been reported to be amplified and expressed at high level in human small cell lung carcinomas. The presence of three sequence motifs in the c-Myc COOH terminus, including the leucine zipper, the helix-loop-helix and a basic region provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibit appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad and Mxi1, and Mad-Max dimers have been shown to repress transcription through interaction with mSin3.

Clonality	Polyclonal
Isotype	IgG
Host Species	Rabbit
Tested Applications	WBIPIFIHCELISA
	recommended for detection of c-Myc p67 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine and feline:
Species Reactivity	HumanMouseRat
Concentration	200 μg/ml
Purification	Affinity purified

Alternative Names	epitope mapping within the C-terminus of c-Myc of human origin
Tissue Specificity	epitope mapping within the C-terminus of c-Myc of human origin

Entrez Gene	4609

Application

Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear and cytoplasmic localization.
Application

Western blot analysis of c-Myc expression in non-transfected: (A) and mouse c-Myc transfected: (B) 293T whole cell lysates.
Application

Western blot analysis of c-Myc expression in Jurkat whole cell lysate.
Application

Immunoperoxidase staining of formalin-fixed, paraffin-embedded mouse uterus tissue showing nuclear localization.

Application Notes	recommended for detection of c-Myc p67 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including canine and feline:

Form	Liquid
Storage Instructions	For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20oC or below. Avoid multiple freeze-thaw cycles.
Storage Buffer	phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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